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1、PleaseprovideemailaddressandORCIDforallauthors.Pleasevisithttp:/orcid.org/forORCIDregistration.ThemaintextandformaltablesofmanuscriptshouldbepreparedinWordfile,justifiedand1.5spacing.SupplementarytablescanbesubmittedinExcelformat.Standardfiguresizesare85mm(singlecolumn)and175mm(doublecolumn)forwidth
2、verticallyor238mmhorizontally.Pleaseadjustthefontsizeforclarity.Thefigureformatcanbeinppt,ai(illustrator),jpeg.PleaseaddlinenumbersinyourmanuscriptandmakesurethebuiltPDFforsubmissionhasthecorrespondinglinenumberstoo.ThereisnoAbbreviationsection,pleasespellthetermsinfullatfirstmentionandputtheabbrevi
3、ationafterwardsinparenthesis.TitlepageArticleTitleInsertarticletitlehereNote:WecapitalizethefirstletterofeachcontentwordforthearticletitleintheactualarticleandTOC.Forprepositionwords,iftherearemorethan5letters,thefirstlettershouldbeinuppercasetoo.Likebetweenshouldbe“Between”inthetitle.Thetitleshould
4、beinboldandthefontsizeshouldbe15.Aligntotheleft.Sample:TheAssociationBetweenH3K4me3andAntisenseTranscriptionAuthor(s)NamesInsertauthor(s)nameshereFirstNameMiddleNameFamilyNamel,Note:Thereisacommabetweentwonames,no“and”beforethelastauthor,sname.WeprefertousenumbersinsteadOfletterstolabeltheauthors5in
5、stitutionassuperscript.Weprefertouse*topresentthecorrespondingauthor(s),andusetopresenttheequalcontributionauthor(s).Sample:HuanmingYang巴DonaldJ.Zack2*,SongnianHUL,Jun丫/产Author(s)AddressInformationInsertauthor(s)addresshere1 DepartnientZInstitute,University,CityPostalcode,CountrySample:2 BeijingInst
6、ituteofGenotnicsfChineseAcademyofSciences,Beijing101300,China3 DepartmentofMolecularBiologyandGenetics,JohnsHopkinsUniversitySchoolofMedicine,BaltimoreMD2/287,USASymbol#Equalcontribution.+Correspondingauthor(s).E-mail:Correspondingauthor(s)E-mailCorrespondingauthor(s)lastnameandinitialsoffirstandmid
7、dlenames(withacommabetweentwoauthors)SampleforE-mail:E-mail:junyu(YuJ),husn(HuS).Runningtitle:Note:nomorethan50characters,italic;capitalizetheinitialletterofeachcontentwordThefirstauthorname/Runningtitle.Nodotsinbetween.Ifonlytwoauthorscontributedtothework,thenusebothnamesratherthanetal.Sample:Runni
8、ngtitle:YangHetal/CorrelationofH3K4me3andAntisenseTranscriptionRunningtitle:MehrotraSandGoyalV/RepetitiveSatelliteDNAinPlantsPleasealsoindicatethetotalcountsofwords,figures,tables,supplementaryfiguresandsupplementarytables.AbstractpageAbstractInsertabstracthereNote:Thissectionshouldbeinoneparagraph,
9、unstructured,lessthan250words.Sample:AbstractHistoneH3lysine4trimethylation(H3K4me3)iswellknowntooccurinthepromoterregionofgenesfortranscriptionactivation.However,wheninvestigatingtheH3K4me3profilesinthemousecerebrumandtestis,wediscoveredthatH3K4me3alsohasasignificantenrichmentatthe3endofactivelytra
10、nscribed(sense)genes,namedas3H3K4me3.3,-H3K4me3isassociatedwith15%ofprotein-codinggenesinbothtissues.Therefore,wespeculatethatthese3r-H3K4me3-markedregionsmayserveaspotentialpromotersforantisensetranscriptionand3-H3K4me3appeartobeauniversalepigeneticfeatureineukaryotes.Ourresultsprovideanovelinsight
11、intotheepigeneticrolesofH3K4me3andtheregulatorymechanismofantisensetranscription.KEYWORDS:Insertkeywordshere;InsertkeywordshereNote:Thereshouldbe3-5keywords,withasemicolonbetweentwokeywords,andcapitalizethefirstletterofeachkeyword.Keywordusedtoextendthesearchablepossibilitiesforyoumanuscript,thusiti
12、srecommendedtousewordsthatdidnotappearinthearticletitle.Sample:KEYWORDS:Calciumtransporter;Sorghum;Rice;GenomicannotationTextbodypageThroughoutthepaper,pleasechecktheusageofproteinandgenesymbols,abbreviations,andnames.Proteinabbreviations/symbolsarenormallyinRomanfont(uprighttype),whilethegenesymbol
13、s/namesshouldbeinitalics,normallyinuppercaseforhumangenes(e.g.,CMHlandHPR)andinlowercasewithaninitialcapitalforanimalgenes(viz.mouse;e.g.,HraslandTcra).IntroductionInsertintroductionhereNote:Noindentbeforethe1stparagraphofaseparatesectionisnecessary.Usesquarebrackettoshowthereferencenumberinthetext1
14、.Andnumberthereferencesaccordingtotheorderoffirstappearanceinthetext.The1stparagraphshouldaligntotheleft,withnoindent.However,formthe2ndparagraph,thereshouldbea3-letterindent.1.5spacesarerecommendedthroughoutthewholemanuscript.Sample:IntroductionThemembrane-associatedcalciumtransporterproteinsareess
15、entialtomaintaincalciumhomeostasisundernormalphysiologicalconditionsandprovidetoleranceagainstvariousstresses.Therearethreemajorclassesofcalciumtransporterproteins:channels,ATPases(pumps)andexchangers16.Membersofthesetransporterproteinsmaydifferintheircellularandtissuedistributionandregulationbyothe
16、rsignalingpathways7,8.ThespatialandtemporalregulationOfcalciumconcentrationinplantcellsdependsonthecoordinatedactivitiesofchannelsandactivetransporterslocatedondifferentorganellesandmembranes9.ResultsInsertresultshereNote:TheIst-Ieveltitleshouldbeinthefontsizeof14andinbold.The2nd-leveltitleshouldbei
17、nboldwiththesamefontofthetext(size12).The3-leveltitleshouldbeinitalicwiththesamefontofthetext(size12),notinbold.Onlythefirstletterofasubtitleneedstobecapitalizedunlessspecifictermsareused.Thesubtitlesshouldbeputinseparatelinefromthefollowingparagraphs.Allfiguresandtablesshouldbenumberedintheorderoff
18、irstmention.Thenameofspecificfigureortableshouldbeputinboldatfirstmention.Thenameofsupplementaryfigureortabledoesnotneedtobeputinbold.Sample:ResultsTheVendenrichmentofH3K4me3intervalsWealignedChIP-seqreadstothe3endofthesegenesandobservedthatthereisaconsiderableincreaseofH3K4me3densityaroundthe3endof
19、3-H3K4me3-markedgenes(Figure1).Theresultofreadprofilingsuggestedthatmodifiedhistonesareconcentratedbothupstreamanddownstreamoftranscriptionalterminationsites(TTS),peakingat-1kbupstreamofTTS.CorrelationofH3K4me3andantisensetranscriptionInthetwomousetissuesexamined,weidentified2,519genesintotalassocia
20、tedwith3z-H3K4me3,ofwhich31%(785genes)aresharedbybothtissueswhiletheremainingisspecifictoeithercerebrumortestis(Figure2A).Themajorityofthe785sharedgenesareprimarilyinvolvedintheregulationoftranscription,metabolicprocessesandbiosynthesis,whichareallessentialcellularfunctions(Table1).Incontrast,thetis
21、sue-specificgenesarerelatedtodevelopment.Forexample,689genesthatshow3H3K4me3incerebrumonlyareassociatedwithcerebrum-specificexpression(TableSI).DiscussionInsertdiscussionhereNote:ThissectioncanbecombinedwithResultssection.ConclusionInsertconclusionhereNote:Thissectionisanoptionalsection.Materialsand
22、methodsInsertmaterialsandmethodshereNote:Theformatofthissectionshouldbeconsistentwithprevioussections.Authors9contributionsInsertauthors,contributionshereNote:Thissectionisarequiredsectiontoindicatecontributionfromeachauthor.Andthereisnodoteforauthorinitialsinthissection.Sample:Authors9contributions
23、ABcarriedoutthemoleculargeneticstudies,participatedinthesequencealignmentanddraftedthemanuscript.JYcarriedouttheimmunoassays.MTparticipatedinthesequencealignment.ESparticipatedinthedesignofthestudyandperformedthestatisticalanalysis.FGconceivedofthestudy,andparticipatedinitsdesignandcoordinationandhe
24、lpedtodraftthemanuscript.Allauthorsreadandapprovedthefinalmanuscript.CompetinginterestsInsertauthors5competinginterestshereNote:Thissectionisarequiredsectiontodeclareanycompetinginterest.Sample:CompetinginterestsTheauthorshavedeclarednocompetinginterests.AcknowledgementsInsertacknowledgementshereNot
25、e:Pleaseacknowledgethefundingagenciesifavailable,providethefullname(includingcountryname)oftheprogramandgrantNo.Pleasealsoacknowledgepeoplewhohelpwiththestudyormanuscriptpreparation.Sample:AcknowledgementsThisworkwassupportedbytheNationalInstitutesofHealthofUSA(GrantNo.R01GM088342)awardedtoYX.Wethan
26、kZhixiangLufortestingPrimerSeqandperformingRT-PCRexperiments.ReferencesInsertreferenceshereNote:ThereferencestyleforGPBis“Vancouver“systemasshownbelow.Text:Indicatereferencesbynumber(s)insquarebracketsinlinewiththetext.Theactualauthorscanbereferredto,butthereferencenumber(s)mustalwaysbegiven.1.ist:N
27、umberthereferences(numbersinsquarebrackets)inthelistintheorderinwhichtheyappearinthetext.CheckJournalsinNCBIDatabasesfortheproperabbreviationofjournalname(http:/www.ncbi.nlm.nih.gov/nlmcatalog/journals).Noteshortenedformforlastpagenumber,e.g.,51-9,Formorethan6authors,thefirst6shouldbelistedfollowedb
28、yetal.”Forfurtherdetailsyouarereferredto44UnifbrmRequirementsforManuscriptssubmittedtoBiomedicalJoumals(JAmMedAssoc1997;277:927-34),seealsohttp:/www.nlm.nih.gov/tsd/serials/terms_cond.htmlPleasemakesureallthespeciesnamesareputinitalicsinthereferencelist.ThetemplateforEndnoteoutputstyleusedinGPBcanbe
29、downloadedat.Samples:Referencetoajournalpublication:1 VanderGeerJ,HanraadsJAJ,LuptonRA.Theartofwritingascientificarticle.JSciCommun2000;163:51-9.2 ZhengL,FoleyK,HuangL,LeubnerA,MoG,OlinoK,etal.Tyrosine23phosphorylation-dependentcell-surfacelocalizationofannexinA2isrequiredforinvasionandmetastasesofp
30、ancreaticcancer.PLoSOne2011;6:el9390.Referencetoabook:3 StrunkJrW,WhiteEB.Theelementsofstyle.3rded.NewYork:Macmillan;1979.Referencetoachapterinaneditedbook:4 MettamGR,AdamsLB.Howtoprepareanelectronicversionofyourarticle.In:JonesBS,SmithRZ,editors.Introductiontotheelectronicage.NewYork:E-PublishingIn
31、c;1999,p.281-304.Referencetoconferenceproceeding/abstract:5 YasudaN,TakagiS-i,ToriumiA.Spectralshapeanalysisofinfraredabsorptionofthermallygrownsilicondioxidefilms.ApplSurfSci1997;117-118(June(11):216-20.ReferencetoanebookoronlinePDF:1 SmithK.AbriefhistoryofNCBsformationandgrowth.In:TheNCBIhandbookI
32、nternet.2nded.Bethesda:NationalCenterforBiotechnologyInformation;2013,http:/www.ncbi.nlm.nih.gov/books/NBK148949/.2 NationalResearchCouncil(US)CommitteeonMappingandSequencingtheHumanGenome.Mappingandsequencingthehumangenome.WashingtonDC:NationalAcademiesPress;1988,http:/www.ncbi.nlm.nih.gov/books/NB
33、K218252/.3 USCongress,OfficeOfTechnologyAssessment.Mappingourgenes-theGenomeProject:howbig,howfast?Washington,DC:USGovernmentPrintingOffice;1988,http:WWWQmLgOVscitechresourcesHUmanGenome/Dublicat/OTAreDon.pdfReferencetoanebookoronlinepdf:4 SmithK.AbriefhistoryofNCBsformationandgrowth.In:TheNCBIhandb
34、ookInternet.Bethesda:NationalCenterforBiotechnologyInformation;2013,http:/www.ncbi.nlm.nih.gov/books/NBK148949/Pleasedonotputwebpagelinksintothereferencesection.Thelinkscanbeaddedinaparenthesisrightafterthecitingmaterialsinthemaintext.FigurelegendsInsertfigurelegendshereNote:Inthissection,pleaseincl
35、udefiguretitles,figurelegendsandtabletitles.Figurelegendsshouldbeinboldin14-pointfont.Weputfiguretitles(12-pointfont)inbold.Andwespellout“Figure”inthetitleline(noabbreviationoffig).Thefiguretitleshouldbeinthesamelinewiththefigurenumber(twospacesinbetween).Nofullstopdot.attheendofthefiguretitles.Thel
36、egendsshouldbeinregularfontsinseparatelinesandinthelegends,onlythepanelindexlabelling(A,B,C.)isinbold.Andthereisafullstopdot.”attheendofthelegend.Samples:FigurelegendsFigure1Comparisonofgeneswith3r-H3K4me3betweenmousecerebrumandtestisA.Numbersoftissue-specificgenesmodifiedwith3-H3K4me3andgenesshared
37、bybothcerebrumandtestis.Thereare785genescommonlymodifiedinbothtissues,689uniquely-modifiedgenesinthecerebrum,and1,045uniquely-modifiedgenesinthetestis.B.TheWntlandStoxlgenes,asexamples,showtissue-specific3H3K4me3.WeexaminedthedensitiesofH3K4me3(red)andpan-H3(green)forbothgenes.Figure2H3K4me3andH3K27
38、me3modificationsaroundTSSProfilesofH3K4me3modificationsacrosstheTSSwereshownforhigh,medium,low,ambiguous,andsilentexpressiongenesincerebrum（八）andtestis(B).ProfilesofH3K27me3modificationsacrosstheTSSwereshownforhigh,medium,low,ambiguous,andsilentexpressiongenesincerebrum(C)andtestis(D).TablesInsertta
39、blelegendshereNote:Thetabletitle(12-pointfont)shouldbeinboldandinthesamelinewiththetablenumber(twospacesinbetween).Nofullstopdotn.attheendofthetabletitles.SampleTable1PathwayclassicationofgenesbasedonKEGGanalysisSupplementarymaterialInsertsupplementarymateriallegendhereNote:Inthissection,pleaseinclu
40、desupplementaryfiguretitles,figurelegendsandtabletitlesasyoudofortheFigurelegendssection.Youcanalsoincludethetitleforsupplementaryfile(includingfilename,fileformat,nameandURLlinkofappropriateviewerifformatisunusual.)FilesforfiguresandtablesFiguresandtablesNote:Figuresandtablesshouldnotbeembeddedinth
41、emaintext;insteaduploadthemseparately,1figure/tablein1file.TablesNote:Weusethree-linetablesandputtabletitlesinbold.Thetabletitleshouldbeinthesamelinewiththetablenumber(twospacesinbetween).Nofullstopdot.attheendofthetabletitles.Thetableheadershouldbeputinbold.Footnotecanbeaddedunderthetableforexplana
42、tion.Andthereisafullstopdotattheendofthenote.OnlythewordNote:shouldbeitalic.Sample:Table1PathwayclassicationofgenesbasedonKEGGanalysisCategoryMappedcontigsSingletonsTotal%Metabolism11410923028.01Humandiseases687514317.41NotePercentageofenrichedpathwaysinbuffalomuscletissuewascalculatedafteranalysisw
43、ithKEGGpathway.FiguresNote:Pleaseputthepanelindexontheupperleftcorneroftherespectivepanel;asteriskcouldbeusedforsignificanceandnoterms(e.g.P0,05)isneededinthefigure;Forthelimitedspace,pleaseprovidethemeasurementunitintheendoftheaxisterms(ngml).Figuresshouldbeofhighresolution.Pleaseuse“Arial“forfonts
44、tyle.Inalltextboxes,onlythefirstletterofthefirstwordshouldbeputinuppercase,unlessspecifictermsareused.Axistitlesshouldbeprovidedforallgraphs;legendboxshouldbeputwithintheplottingareawheneverpossiblewithoutborders.Standardfiguresizesare85mm(singlecolumn)and175mm(doublecolumn)forwidthverticallyor238mmhorizontally.Pleaseadjustthefontsizeforclarity.Pleaseprovidetheeditableversionifpossible.Ifyouadoptormodifythefigurefromthosepublishedpreviously,pleasegetthepermissionfromtheoriginalauthorsorjournals.
