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1、Effect of a resistant dextrin on satiety and weight management抗性糊精对饱食与体重控制的作用,Study design研究设计,Satiety饱食,Hunger feeling饥饿感,Food intake食物摄入,STUDY DESIGN研究设计,Objectives,Study description,Population,Study product administration,Groups,Parameters,Schedule description目的、研究描述、人群、研究产品服法、群组、参数、日程描述,RESULTS结
2、果,Satiety,Hunger feeling,Caloric&Food intake,Bodyweight,Body fat饱食、饥饿感、热量及食物摄入、体重、体脂,CONCLUSION结论,Bodyweight体重,Bodyfat体脂,Part I:Study Design第一部分：研究设计,Study design研究设计,Satiety饱食,Hunger feeling饥饿感,Food intake食物摄入,Bodyweight体重,Bodyfat体脂,Study design,Objectives:Evaluation of the impact of a resistant de
3、xtrin on satiety,food intake and weight management评价抗性糊精对饱食、食物摄入和体重控制的影响Evaluation of the impact of a resistant dextrin on hunger feeling and body fat评价抗性糊精对饥饿感及体脂的影响,Study design研究设计,Satiety饱食,Hunger feeling饥饿感,Food intake食物摄入,Bodyweight体重,Bodyfat体脂,Study description(研究描述)Randomized,placebo-control
4、led,double-blind,parallel,single center随机、安慰剂对照、双盲、平行、单中心Implemented in China 在中国实施,Study design研究设计,Satiety饱食,Hunger feeling饥饿感,Food intake食物摄入,Bodyweight体重,Bodyfat体脂,Study design,Population(人群)20 healthy overweight Chinese volunteers per group(5 groups 20 volunteers)每组位健康超重中国自愿者（组自愿者）Men and women
5、(50/50)男性与女性（）35 to 55 years old35 到 55 岁Overweight(24 BMI 28 kg/m2);Chinese cut-off points for overweight超重（24身体质量指数28公斤米2）；中国超重切分点Factory workers工厂工人：working 7 days a week at Li Pu manufacturing plant荔浦制造厂每周工作天eating at the canteen at every meals每餐在食堂就餐,Study design,Administration(服法)Two daily int
6、akes of a resistant dextrin in 250ml orange juice将抗性糊精融入250毫升橙汁，每天摄取两次Placebo arm:Orange juice安慰剂组：橙汁Treatment arms:Resistant dextrin at different dosages in orange juice治疗组：在橙汁中加入不同剂量的抗性糊精,Study design研究设计,Satiety饱食,Hunger feeling饥饿感,Food intake食物摄入,Bodyweight体重,Bodyfat体脂,Study design,Parallel stud
7、y(平行研究)Group 1:Placebo组1：安慰剂Group 2:4g resistant dextrin 2 intakes=8g/day组2：4克抗性糊精 2次摄取 8克天Group 3:7g resistant dextrin 2 intakes=14g/day组3：7克抗性糊精 2次摄取 14克天Group 4:9g resistant dextrin 2 intakes=18g/day组4：9克抗性糊精 2次摄取 18克天Group 5:12g resistant dextrin 2 intakes=24g/day组5：12克抗性糊精 2次摄取 24克天,Study desig
8、n研究设计,Satiety饱食,Hunger feeling饥饿感,Food intake食物摄入,Bodyweight体重,Bodyfat体脂,Study design,Schedule description,Breakfast,7:00am,Lunch,12:00-12:30pm,Dinner,6:30pm,Placebo or resistant dextrin,Placebo or resistant dextrin,10:00am,4:00pm,Hunger feeling questionnaire(9:50am),Hunger feeling questionnaire(3:5
9、0pm),Satiety evaluation(VAS)from 10:00am to 12:00am,Satiety evaluation(VAS)from 4:00pm to 6:00pm,Food intake evaluation,(*),(*),(*),(*),Study design研究设计,Satiety饱食,Hunger feeling饥饿感,Food intake食物摄入,Bodyweight体重,Bodyfat体脂,Study design,Part II:Results第二部分:结果,Satiety 饱食 Hunger feeling 饥饿感Food intake 食物摄
10、入 Body weight 体重 Body fat 体脂,Study design研究设计,Satiety饱食,Hunger feeling饥饿感,Food intake食物摄入,Bodyweight体重,Bodyfat体脂,Satiety evaluation by VAS饱食评价（按视觉模拟评分法）,The resistant dextrin has a positive and significant impact on satiety just after the first consumption at 14g,18g and 24g/day.在首次摄取14克、18克和24克天后，抗
11、性糊精对饱食有积极且明显的影响。,DAY 0,Orange juice consumption,Hunger feeling饥饿感,Food intake食物摄入,Bodyweight体重,Bodyfat体脂,Study design研究设计,Satiety饱食,Satiety evaluation by VAS饱食评价（按视觉模拟评分法）,DAY 21,From day 0 to day 21,the resistant dextrin has shown a progressive and strong impact on satiety.At day 21 and before day
12、21,the resistant dextrin has shown a significant modulation of satiety at 8g,14g,18g and 24g/day.从首日到第21日，抗性糊精已显示出对饱食有渐进及较强的影响。在第21日及之前，每日摄取8克、14克。18克及24克/天，抗性糊精已显示出对饱食有明显的调节作用。,Orange juice consumption,Hunger feeling饥饿感,Food intake食物摄入,Bodyweight体重,Bodyfat体脂,Study design研究设计,Satiety饱食,Satiety evalu
13、ation by VAS饱食评价（按视觉模拟评分法）,The effect of the resistant dextrin on satiety is time correlated and the effects are clear from day 0.抗性糊精对饱食的作用与时间相关，且从首日开始有作用。,Orange juice consumption,Hunger feeling饥饿感,Food intake食物摄入,Bodyweight体重,Bodyfat体脂,Study design研究设计,Satiety饱食,The consumption of the resistant d
14、extrin has a positive impact on the hunger feeling score over the study period with a statistical difference from day 5.在研究期间，使用抗性糊精饥饿感评分有正面影响，从第天起有差异。,Food intake食物摄入,Bodyweight体重,Bodyfat体脂,Study design研究设计,Satiety饱食,Hunger feeling饥饿感,Hunger feeling饥饿感,Hunger feeling饥饿感,The number of volunteers,who
15、 are not hungry,has increased over the study period with a dose-effect relation.不饿的自愿者人数在研究期间增加，具有量效关系。,Food intake食物摄入,Bodyweight体重,Bodyfat体脂,Study design研究设计,Satiety饱食,Hunger feeling饥饿感,Food intake食物摄入,The resistant dextrin has shown a significant decrease in food intake at lunch over the study pe
16、riod,from week 3.从第周期，抗性糊精在研究期间明显减少午餐食物摄入量,Bodyweight体重,Bodyfat体脂,Study design研究设计,Satiety饱食,Food intake食物摄入,Hunger feeling饥饿感,Body weight体重,The resistant dextrin has shown a significant decrease in bodyweight from-0.42kg at 14g/day.This weight lost became higher with the increase of the dosage of t
17、he resistant dextrin.用量为克天时，抗性糊精明显减少体重 0.42公斤起。随着抗性糊精用量增加，减重更大。,Bodyfat体脂,Study design研究设计,Satiety饱食,Hunger feeling饥饿感,Food intake食物摄入,Bodyweight体重,Body fat体脂,The resistant dextrin has shown a significant decrease in body fat from-0.12%at 18g/day.This body fat decrease became higher with the increas
18、e of the dosage of the resistant dextrin.用量为克天时，抗性糊精明显减少体重.起。随着抗性糊精用量增加，体脂继续减少。,Study design研究设计,Satiety饱食,Hunger feeling饥饿感,Food intake食物摄入,Bodyweight体重,Bodyfat体脂,Part III:Conclusion第三部分：结论,Study design研究设计,Satiety饱食,Hunger feeling饥饿感,Food intake食物摄入,Bodyweight体重,Bodyfat体脂,ConclusionS,There is a lo
19、gical correlation between the biomarkers leading to an overall improvementThe daily inclusion of the resistant dextrin induces a progressive impact on satiety,inducing positive effects on the decrease of the food intake,with a direct impact on the management of bodyweight and body fat.This study sho
20、ws a clear dose-effect relation造成整体改进的生物标志物之间存在逻辑相关性日常摄取抗性糊精对 饱食产生渐进影响，对食物摄入的减少产生积极的作用，对控制体重和体脂有直接影响。本研究显示出清晰的量效关系,Study design研究设计,Satiety饱食,Hunger feeling饥饿感,Food intake食物摄入,Bodyweight体重,Bodyfat体脂,The RESISTANT DEXTRIN has demonstrated strong effects in satiety and weight management抗性糊精饱食和体重控制具有强效,ConclusionS,Study design研究设计,Satiety饱食,Hunger feeling饥饿感,Food intake食物摄入,Bodyweight体重,Bodyfat体脂,
