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1、MEXrOCyf1.APCTBEHHbIiiCOBET110CTAHAAPTM3A1.(SH,METPonorMHSCEPTHHKAUHW(MC)INTERSTATECOUNCI1.FORSTANDARDIZATION.METRO1.OGYANDCERTIFICATIONOCT326342020(SC)MEKOCyAAPCTBEHHb1.kiCTAHAPTMeTOIqb1.HCnb1.TaHk1.访nobo3A6mctbmk)xmmmm6Ckom11po1.qyMhMHaopraHM3MUeJIOBeKaPA3BEf1.AHMEKOXWINVITROMeTOAb1.CMC11OJ1b3OBaH
2、MMPeKOHCTPyHPOBaHHO。MeJ1.OBeHeCKOro311MApMMCa(OECD431:2016,Guide1.ineforthetestingofchemica1.s.Invitroskincorrosion:reconstructedhumanepidermis(RHE)testmethod,MOD)3AaHyeoH11ManbHoeMocaCaHAapwHopM202111peAMcnoBne1.4e11M,OCHOBHbie11pMHqnnbho6uvte11pavnanp。BeAeHumpa6onoMexrocyAapciBeHHowCTaHapw33unnyca
3、HBnebOCT1.0MexrocyAapcTBeHHaRcwciewaCTaHAaPTH3a4nn.OCHOeHb1.enonoxeHMMOCT1.2MexrocyaapcTBeHHaf1.CMCTeMacaHaapwaunn.CraHf1.apTbiMexrocyf1.apcTBeHHbie.npaonnaHPeKOMeHAaUHHnoMexrocyAapcBeHHMCTaHAaPTM3aux.11pannapaspa6ov,11pwhriha,06HOBneHvmMOTMeHb1.ACbcaohma0CTaHAaPTC1 11O11OTOB11EHPec11y611naHCKMMywwa
4、pHWM11peA11pnRTMMBenopyocKMviryapceHhbiMHCTMTyrMponorHM(BhMM)a0CH0Mco6ctbghhoonepeeoaHapyccMA3baHr1103bHH0wepcunAOKyMeHa,ya3aHH0r0B11ye52 BHECEHocyf1.apciBHHbMkommttomnocaHapw3auMwPecny6nnnBenapycb3 11PMHATMjrocyapcBHHbMcobiomnocaH4apTM3auww.MeTPOnOrMHMcpnnauMM(pooono30AHBapf1.2020r.Ns126-11)3a11pwH
5、Rve11poronBa11n:KPaTKOeHaHA4H0BawnCTPaMHnoMKIweo3166)00497ApMCHMf1.BenapycbKa3acaHKnpW3MAPoccmaTa*MKncaHy36eHCaHKCTPQXHnoMKHCO31661(XM97AMBYKZKGRUTJUZCxpam9HH0k8hw8xo3h阳HauMwabHcoopra11aoCTaHaapTHjauMK3A0onorw11jPec11y6nnMApmghmroccaHAapPec11y6nnMSenapycboccaHf1.apPc11y6nnMKaaaxcraHKbprw3CaAapPoccTa
6、Hf1.aprT0xnaHf1.apy3caHap4 11pna30MeaepantHoroareHTCaoTeXHMqeCKOMyPerynKPoeaHMK)wMeponornMo18waA2021r.Nq376-ctMeMOCyAaPCTBeHHbiiCTaHQaPTOCT326342020BBe4eHBewconeBKaUeCYBea-UWOHanbHoroCTaHAaPTaPoccwcoieAepau11c1HiOna2021r.5 HacTOf1.iUkiMcaHapf1.0nf1.ecf1.MonHnupOBaHXb1.MnoOTHOineHHK)MeMyHaPoAHOMyAOKy
7、MHyOECD431:201611PyoBACTonoTeCTv1.POBaHHK)XMMMMeCXHXBeIUeCYB.PaabeAaHweKO)KMinvitro:ZeTOAKCnbITaHH只PeKOHCTPyMPoBaHHorOMenOBeUeCKOro311MAepMvca(RHE)(Guide1.ineforthetestingofchemica1.s.Invitroskincorrosion:reconstructodhumanepidermis(RHE)testmethod-.MOD)11yeMM3weHeHurerocpyypbAnanpMBef1.eHHRbcooBecne
8、c11paBMaMM.ycaHneHHbMnbOCT1.5110pa3-aenw4.2m4.3).MexAyHapOAHbiiiAoKyMeHrpa3pa60aHOPraH1.43auneaoHMVMecoro8pyAHmCrBanpa3MTMROECD(OrganisationforEconomicCooperationandDeve1.opment).HanweHOBaHMeHaCTOaIUerOCraHAaPTam3mhhoOTHoCHTenbHOHaHNeHOBaHKaya3aHH0r0wey-Hapof1.HoroAOKyZeXTaayA3KHcHaV1.MeKOBaHHaMs.np
9、viHATbiPZMbCymeCTByKxMeMowneceMe)rocy-AapcTBeHHbixCTaHf1.aPtob.ConocaneHMeCTPyKTyPb1.HaCTOame0cauapa8cpyypovyaaHHoMeWyHaPo刖。ao-ywHa11pwBef1.eHbAOnonHHTenbHOMnpwnoxeHUM11A6B3AMEHOCT32634-2014k1.HopMaauf1.oeee11uueucmue(npepatueHuueucmuff)MaCmoameocmandapmauu3Me-HenuuHeMyHameppumopuuya3QHHNbteaocyapcm
10、ny611uyemcf6ya3amenHaUUoHaRbHbfXCmaxdapmoeu3aeaeMbtxe3mu2ocyapcma,amaxcemuMMmePHom11acaumacoomemcmy-KWUXHawoHa11bHOpeaHO8nocmandapmuauuu.BCfiyyao6pecMompa.u3MenenuuuomMGHuUaCmoQUXe&cmandapmacoomeemcmeytomafiuh-opMaw6yemo11y611oaHaHa0ua11bH0MUHmepnem-caumeMeocyapcmeHHoocoemanocmaHapmu3auu,Memponoauuu
11、cepmuauuuKamanoMMe)xeocydapcmeeHHbteCmaHdaPmbSCaHf1.apIHHpF,00pF11GHH,2021BPoocwhckoweAepauwwHaCTOa山w口ca11apHeMO)KeT6wb11o11HorbK)w11wHaCTHMHoBc11pow3BeAeH,TwpaxnpoBaHHpacnpocpaHHbKaUecIBeowuna11bHoroM3AaHHA6e3pa3peHMAe4panbH0r0areHcBanoTeXXkNeCKOMyPerynUPOBaXHK)HMeTPonOrMHBBeAeHHePa3eAaHneoncor11ac
12、HOnPe(QeneHK),npHBef1.eHHOMybCornacoBaHHoviHano6a11b11Mypo-HecnceMeKnaCCV1.nauHHMaPKMPOBKHXKMMHeCK11poAyunnOpran3aunnOSbeAHHeHHbixHaqnw(CCOOH)1,npe4caBnf1.eco6omHo6paMMoe0BpeM(AeHMekoxm.oopoepBnf1.ecf1.BHaHMb1.MHep030M31111AepMucawAePZb1、11ocneHaHeCeHVmHaoyHCCneayeMQaXHMHUeCKOii11poAyu11M-O6hob-ne11
13、Haf1.PeAaXUWaPyXOBOAeT8anonpoeeaeHHK)HCnb1.TaHH口Na431(OECD431),HaOCHOBeooporoorooB11eHaCTO只WHncaHap,ycaHaBnnaeMeTOAinvitro.113onAoi4MMHeHnwunpoBabBeIUeCTBanCmneHj1.HHeBbObiBaKJmnepa3beaneko)km.KaKaonpeycMpeHpe6B3HMAMHCCOOH(1.AaHHOePyKoBOACrBOo6ec11HMaeB3M*HbnaccMuauMk11poAyu11H.0611aAau4eMpa3be4amMM
14、4etcBnew.Ha8。TBeTCTBymne110naccbOnaCHoCTx.OqHacco6hoctwXMMHMecKOM11poAyMMBb3bBabpa3bezaHeoxMo6whho11peA11onaraenc-onb3BaMena6opaop11bxXMBOTHb1.X(PyKoBOACTBoOECDnonpooeenMK)HCnbITaHH伪NQ404(OECD404);BnepBbie11pnHRob1981r.,11epecM0peH0b1992,2002S2015rr.)(2.BAOnOnHeHKeKMeTOIQyOECD431anHjQHpB3HbMp11HATbT
15、ax)KeABaAPyrMXMeTOaaMCnbITaHK1.iinOaPeAez1.eHHapa3be4ameroAeMCTBMRXHMHHCKOW11pAyKQMH.11pviBAeHHba)iuerohpa3b6Aa)iueroAeMCTBKaHaoxy,BntHaBc6aHeCXOnbKOMAyne,bnpeenaxoopbixCrpynnHpoeaHbip11MeHAeMbiemctomhmkwHHopMaqMHMMeToAb1.MCCneAoeaHiriM.KCOaeP)KMTHe-06x0AHNHeya33HHR,acau4t1ecR:(i)06061.MeHHaMHCnonb3
16、。HaHVmHMeK)IUHXCaAaHHbix,11onyHHHbxbxoaeHCnb1.TaH而nnnhhumnyewQnaOUeHKHc11oco6hocthXKMhHeCKo1npoayunwb3bBabpa3jQpaxe-HueMpa3bezaHMekoxm,aTaKXe（三）b6opaOnTMMaJ1.bHOrO110A0Aa11pB3HMKHBHMv11ope6HcnbAononHmenbHNXMCnbrraXMaX6.f1.oyMHOECD4316bnnepb11pmhrtb2004r.1.a3aenaKAb110Aeprancf1.S3MeHeHHaz:b2013r.oraH
17、ero6bnnBKniOYeXb1.AOnOnHHTenbHb1.eMeToAb1.WCnb1.TaHWHHaPeKoHCTPyvIPOBaHHOM11enoeesecKOMsrwiep”SCe(RhE)cbo3moxhoctbk)11pnweHeHMATaKHXwe00B即11accvauMupa3b-eaatomewxhmhmcckownpoyunncPaMeneHHeMHanoanaccbOnaCHOCY凡mb2015.KorAaoh6bn11pwBHbcooBecBwec11onoxeHMMnpyoBARi4eroAOKyMeHTaIATAhAononHeHOnHCaHHeMa11be
18、p-HawBHoroMeTof1.a03MepHMMxw3HecnocoHcnneM.BOECD431npMBeA6HbYeTb1.PeBanwxpoBaHHbixMeToAaV1.CnbITaHn,KaxAb1.nH3oopbxochob3hHaKCnOnb30BaHWWCePKHXOBbInyCKaeMXXo6pa3uooRhE.Hccne4o0aHWRHaoaepez3pvenbH0HBanH-AaUHV1.7,aTaICKenocneywiMweBanHAaUHOHHbIem811aoBaHHa8-106b1111npoeeeHbibOTHOuJeHHMCDeAyKW1.XAByXMe
19、ToAO,11peACaneHHbx11aPbIHKe11,12:EpiSkinwStandardMode1.(SM)KEpiDermSkinCorrosivityTeSt(SCT)(EP1.-200)(BanHA叩OBaHHbIepeepHTHbMeTOAb1.(BPM).11oHTOraMWCCnef1.oeaHMW6b1.J1.M11Of1.OTOBneHb1.PeK(WeHaUMXBCOOTBeTCT8KKCKOTOPbIMK11pMMeHeHHey11OMHyTb1.XBbiiueBPMboeperocyAapcBeHHoroperynnpoaHHR只QnyCXaeTcf1.11rp
20、a3nn11eHMApa3ba)iuki(P)MHepa3bAaomnx(HP)Bemec0,aEpiSkinwaxerzoxeSCnOnb30BaTbCazwaOaPeAeDeHWapwaA-nexHcnpa3b%aK)IHSXBe14ecBKycanOBneHHbaMAnahhAnaccaMOnaCHOCm13-15.Ka6binoOnpeaeneHOBXOAeBaT1.tVIaUMHHa0cH0enpnHf1.txca11apo3enBHcu.ABaApyrwxcyHNHapbHeMeTOAaHCnbnaHnHapa3beAaHHeo*winWfRCHCnOnb3。BaHHeMMOAen
21、MRhE06ecneHWBa0nonyHenwepe3ynba0B.oopbeaHanorwMHbo11yMaeMNMnv11omouhBPMEpiDerm16-18.f1.aHbieMeToAb1,SkinEthicrwRHEi)MepiCSwwHepaobeqaK)叫XBeiUeCTB19.(20).MccneAOBaHHR,npoeef1.eHHbie11ocneBanHRaUBHH3roowenf1.MnMOf1.eneMRhEb11epnof1.c2012no2014rr.cWCnOJ1.b30BaHHeMAOPa60TaHHorOnpooona11ryeraMeUJaK)IUHXb
22、owmctbmm.B03Hnauwx11pwHcneuwwHecoMboCCraHoBneHWHMTTMccnef1.yemowXHMMMeCKOS11poAyqv*eM,11o3bo11w11wHeo11bo0Bbcnbpe3ynbaviBH0cbpa3wMHHf1.PJHPBemec8.homOnTMMW3叩OBaTbnpoueccOnPeAe;IeHXaw11pHH3AnexHnycaHneHHbF110AnaccawOnaCHOCTH21),22.11ocneAy)uMWcancMMecwMaa-nn3aHHu.nonyMeHHua11aEpiDermSCT,SkinEthicn4RH
23、EHEPiCsnoCDeBanKAaUMK6wnHanpaB-CopaueHHeRhE(ReconstructedhumanEpk1.ennisPeKOKCTPyMPOBaHHbIaMenoBeMecwsnuAepAwc)11pMMeHRTCf1.HR3HaHHMf1.BCXMOAnW.p311H3yMb1.XXaOCHoB8TXH0D0114MRhE.COKPam8HMRHEbo6o3H3mmimMrwSkinEthiCTMmmtotawanorwHyK)paciBMpoBy,11aoaYaCTboproeoroXaHMGHOBaXMaA11f1.cooBecBymeroMeTOaaWCnb
24、1.TaHHAoho3a11ncbBaecHenWXOM3ar11aBHMMn6yB8n.neHHaBbWBneHHea11bepHanBHwxMoAenenp0rH03叩OBaHW凡1106NtuamuBePORTHoCTbnocpoeHHA0c0BepHwx11poho3obBUaCTWpa3e11eHMR11p0y4nHHanonaccb011acH0cn23.AowananapnMHHHABceperocyapcrBHHroPeryJ1.HPoBaHKaaoronn6opA11araeMrono-o6hoownnMf1.wwuMpoBaHHroMeoawc11waHHMHapa3ean
25、eoxwinvitroaMoneDHRhE.onwHHorooBPM,hgo6xoahmoy6MTbCA.htoeroHaAxHcb.POnoBaHTHOCTb(tomhoctb),aTaiOKeorpaHMMeHMf1.,oopweXaCaK)TcAycnoewHero11pe11o11araeMoronpnMeHeHH,COnOCTaBKMb1.cananorMMHHMnnoa3aenf1.MMBPM.HC0f1.n3p6B3HMwCTaHapB94t)nBH0Cin(C3)24)、pa3pa60aHHbxCyM-oM11pwHiwnoBPyXoBOnaWeoAOKyMeHTaND3425
26、.F1.pwcoef1.WHeHneCvICTeMeb39wmhoo11pw3HaHM9AaHHbixrapaHTMpycf1.o11bonpnycoww,htopeaaraeMb4HOBbIAnnnycoBpujGHCTBBaHHbwMeIOAHCnb1.TaHH讯OTBeMawn向pe6oaHHAMC3,yc11euH011poe11PaCCZOTPeHHeHeroOnHCaHKe6wnobk11k-HHOBOECD431.MTOb1.BKK)HGHHb1.BOECD431,MOyrHCnoj1.b30BaYbCaJ1.f1.pMBAHHABo-BeTCTBXepe6oaHvwpe3y11
27、baaMHCnbnaHnHapa3bef1.aneoxninvitro,OAHOBPeMeHHOo6ec11eMMB3A11pH3HaHMHaB3aMMH0W0CH0Mp3ynbTaT0.nOnyMGHHb1.XCWCnOnb30BaHSef19THXMGTOAOB.OCT326342020MEXOCyAPCTBEHHb1.1CTAHf1.APTMeTOAbiHC11baHMHnobo3acmctbhkxhmmmockom11pAyuHMHaopraHH3MMonoBCaPA3,bEf1.AHMEKOXMINVITROMeoAbcHC11onb3BaHeMPeKoHCTPyMPOBaHHooH
28、enoeHecoro311MAepMMcaMethodsforstudyingtheeffectsofchemica1.sonthehumanbody.Invitroskindamage.ReConSIrUcWdhumanepidermismethodsAaaBeeAeHMR202107011 06nacb11pMMHeHHAHacTOAiUMMCTaKaaPTPaCnPOCTPaHaeTC只HanpoeeaeHweHCnwTaHH讯1103B011RKmnxBbIaBHTbxwwwMe-cy11poyKunio,o6naf1.anuypa3beaa)mnMReScTBKeMHaoy.11pn
29、VIenbITaHHaX11peAycMapn8aecKCnOAsaOeaHMeaHaabieaeMoropeHCipynpoaHHoroYOnOBGMexoro3w4pMnca(ReconstructedhumanEpidermis(RhE)(11o11yMaeroroW3HepacopwnpoaHHwxanwAepwanbHbixKePaTHHOUWToBMenoea),AOCTOBpHOHMHTMpyiO1.MGroWCTO11O114HCKW.M0p0n6beA6an.Heo6xoMMwe即8COXPaHeHHaca6n11bHcn11poya,aTaKXe116be11pnwecw.
30、HanXYWeoopwxo6y-CPOBneHOOpMMGHAGMb1.MnpqCCOM.HOMCX11IOHaA11K56b1.paCIBOpMTnw.yAanHMKOTOpbiXHCa3b1.a*ecHaca6w11bHcvBemeCTBawnwHaeroCOCTaBe.1.2 B3)KX(HP1.CHighPerformance1.iquidChromatography):Bb1.COKo3euiBnaaxwf1.ocHaAxpoFaorpan.1.3 ETso：110a3ae11b,3HaMeneooporoMO)KeT6wbOUeHeHOryeMOnPeReneHHaBPeMeHHb
31、o3-AWCTBMA.HO6xOAWMOOA11ACHMXHWRKW3HCn6HOCHKTOKH50%.OC11HCnOnb30BaHHaCT3HAapTHoroxmmmhgckooBemeC1.BacaaaHHbiM3HaHneMKoHUeHIPaUHH(cm.axICso).1.4 xM3Hec11oco6Hcbneo(ce1.1.viabi1.ity):11apaMep,OCPeAenaK)山由CyZMaPHy1.oavBHcbne0MH0wnonynRunn.HanPKMePCnO86HoCTbKneToMXbIXMKrOXOHZIPWanbHbIXAe叩POfeHa3BccaaB-1
32、1nabBHTanbHbiHXPaCHTenbMTT(3-(4,5-AWMTMnMa3on-2-M11)2,5-AneHwnepa311HM6po”w,na-3onnnCMHww).KOTOpbiw.B3a0ncwMcMoM3wepf1.eMoroKOHeMHOfO11oaaenf1.n11pooonaKCnbITaHM凡oppenwpyec06UUIMUWCnOMWA1.nMBbixMBaeMOCTbto11eo.1.5 IATA(IntegratedApproachonTestingandAssessment):MHTerpnpoeaHHbiw11oaoakVICnb1.TaHHaNHou
33、ee.1.6 ICso:110a3aenb,SHaneHVjeooporoMo)KeT6b11bOUeHeHO11yewOnPeAeJ1.eHvmKOHUeHTPaUHHCTaHXiapTHoroB4cBa.npnKOTOP0CHwxacf1.xw3Hcnoco6HCTba11hHa50%(ICso)nohctghghhm33aHHro11epwoaB03f1.ec8n.cm.TaKXeETso.1.7 M3boHHanA03a(infinitedose):KOnHqeeTBoHCCneAyeM。口XMMHMeCKoq11p0Ay4nw,HaHDCKMoAHa3nepMwc.11peBbuja
34、meeonnMec8,oooeHeo6xowwo11onoromaHMepHoro11okpmtmanoeepxHOCTM311HAepMMca.M3AHMeoMUManbHoe1.8 MccneAyeManxMMHHecannpoAyun(testchemica1.):11pyunf1.KOToPaanof1.Bpraecf1.nc-11WTaHHf1.M.1.9 UVCB(unknown,ofvariab1.ecomposition,orofbio1.ogica1.origin):Be14ecBaHen3ecHrom11m11epeMHHroCOCTaBa.11po11ybKOMnneKC
35、Hb1.XPeaKUVIaw11nBe1.UeCTBa6wonorwMecoro11powcoxeHHA.1.10 KOHTponbHaR11po6aHCOHC必，HeCnoCo6hmx(NSCodntro1.):KoH1.POnbHaa11poaAnaOUeHKHHcneuMwHcoroOKPaUJHBaHuaBHxn3HecnocoHbxTKaHax.1.11 KOHTponbHaR11po6aHCMH3Hocnoco6MMx(NSCM11gcontro1.):KOHTPoJ1.bHaa11po6aa11aOUeHKMe-CUHHHCK00OKpai1.JKBaHHf1.BXH3HCOC6
36、Hb1.Xia11f1.x.1.12 MH0r00M110HeHTH0eBe14ecB0(mutinstituentsubstance):BeiueciBO,xapapn3yemoko-JiMMecTBeHHbiMcocaM,BoopowABeSnv1.6oneeOCHOBHb1.eCTPyKTyPHb1.ecocraennioiMweAepxacbKOnWHeCme10%11oMacce),hoKAyCMeCb1.OHMHOrOKOMnOHeHTHbINBeieCTBOMCOCToV1.TBtom.MoCMeCb06pa3yecf1.nyeMCOenHHeHHaAByXwnw6oneeBei
37、UeCTBnpvOTCyYCTBHSXHMUNecKOIipeaUmMhookom11ohhthoBeeco,Ha11poM,06pa3yecf1.bpe3ynbaeXHMHqeCKoaPeaKUHn.1.13 MTT(MTT):3-(4,50MTHTna3on2Hn)2.5AnHnnrpaaonwf1.6pOMWA：TMaaonnnchhmww-pa311MR6poMMA.1.14 Haae*Hcb(re1.iabi1.ity):110a3anboro.HTOmtoaHCnbnaHWnmoxt6bibpeannaoeaHcno-J1.yMeHHeZBc11poM3BMMbpe3y11ba0B
38、bPaMKaXOAHoaV1.nHpa3nnHHbx11a6opaopniibpa3HoeBpesiR11pw11pnMHeHnnoaHoroHoroxe11pooonaOhoueHHaecR11yewBbrMHCj1.eHKaBHyrpw-HMexnaSopa-T0pH0WBOCpOK3BOAMMOCTH(25).1.15 HCMTT(NSMTT):HcnunHMCoBOCCTaHOBneHWeMTT.1.16 HP(NCnoncorrosive):HepasbejQaiomaf1.1.17 OAHOKOMnOMeMTHOeBemeCTBO(Monos1.ituntsubstance):Be
39、iMecreo.XaPaKTePH3y。MOeo-J1.HHGCTBGHHb1.MCOCTaBOM,BKOTOpOMOAHaOCHOBHaf1.CTPyXYyPHaaCOCTaB11AKU4af1.COAepXMTCf1.KOHHH-ceHeMeHeeYeM80%(nowacce).1.18 011(ODoptica1.density):OnTMVeCKaa11noHorb.1.19 11K(PC-positivecontro1.):11onoxwbH3AKOHTpOj1.bHaanpo6a.COAoP)Ka1.MaabcKOMnoHMb1.MccnGAyeMOHCgeNb1.mo6pa6ai
40、bBaMaf1.cwcnonb3BaHMMeemeciea.aaeef1.owoAa1.OUWOnonoxwenb-HbiAonnHo6wo6ecne11nbB3MxocbyMnuBabM3MeHMMBocbboBpeweHMonwa.nonyMaeworoA11f1.110D0KMTnbH0r0KOH1.POn凡3T0T0n0XMTnbMb1.MOTKnWKHAOHXGH6b1.TbCnni1.JKOM3aBb1.UJHHb1.M.1.20 pa3ieAaHMekomwInvivo(skincorrosioninvivo):B3HwoeHMHGoePaTHM(XOop*QeHMRKOXW.K
41、OTOpOp0f1.B119TCf1.BMA1.rIMb1.MHGKpO3OM3MpMWCaHAePMbBO3HHK3O1.Mee11OC11eHaHeCGHMAHeCDeAyeMO口XXMSMeCKo11pozyuwMHacpoAO4M.Pa3beaxueeaewcBne11accwwunpyecnoHa-J1.HHHK)3BKpOBOTHHMW,KPoBaBbaXCTpynbGB,aMpe314CyinoM3MHeHHK)OTIHKaKOXM,BbiaaaHHOMyeeo6ecuBeMuaHweM.110B11eHny11acoBbinaAeHKaBonoC(a11o11eunw)uujpawoB.BCoMHKTenbHbJXcny11aRxAOnXHOp0B0f1.wibCRrMCiona7onorHecoeHCCJIeAOBaH坏。nopaxHHbxyHaco.1.21 pe11eaMTHcb(re1.evance):OnwcaHMecootbtctbmaMeTOAaKCn
